MovDisordV3, France, Analysis, bibRecord, 000630

Levodopa‐induced dyskinesias in Parkinson's disease phenomenology and pathophysiology

Identifieur interne : 000630 ( France/Analysis ); précédent : 000629; suivant : 000631

Levodopa‐induced dyskinesias in Parkinson's disease phenomenology and pathophysiology

Auteurs : Roberto Marconi [France, Italie] ; Dominique Lefebvre-Caparros [France] ; Anne-Marie Bonnet [France] ; Marie Vidailhet [France] ; Bruno Dubois [France] ; Agid [France]

Source :

Movement Disorders [ 0885-3185 ] ; 1994.

RBID : ISTEX:47A4FE5EDF56187C2710121CE25D3FC003824AE1

Descripteurs français

Pascal (Inist)
- Dyskinésie, Homme, Lévodopa, Parkinson maladie, Physiopathologie, Toxicité.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Activities of Daily Living (classification), Adult, Aged, Chorea (chemically induced), Chorea (physiopathology), Dose-Response Relationship, Drug, Drug Administration Schedule, Dyskinesia, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (physiopathology), Dyskinesias, Dystonia (chemically induced), Dystonia (physiopathology), Electromyography (drug effects), Female, Human, Humans, Levodopa, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Motor Skills (drug effects), Neurologic Examination (drug effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (physiopathology), Parkinson disease, Parkinson's disease, Pathophysiology, Receptors, Dopamine D1 (drug effects), Receptors, Dopamine D1 (physiology), Toxicity, Video Recording.
MESH :
- chemical , administration & dosage : Levodopa.
- chemical , adverse effects : Levodopa.
- chemically induced : Chorea, Dystonia, Parkinson Disease, Secondary.
- classification : Activities of Daily Living.
- drug effects : Electromyography, Motor Activity, Motor Skills, Neurologic Examination, Receptors, Dopamine D1.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- physiology : Motor Activity, Receptors, Dopamine D1.
- physiopathology : Chorea, Dyskinesia, Drug-Induced, Dystonia, Parkinson Disease, Parkinson Disease, Secondary.
- Adult, Aged, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Video Recording.

Abstract

The aim of this study was to provide further insight into the phenomenology and pathophysiology of monophasic and biphasic dyskinesias induced by levodopa in Parkinson's disease. For this purpose, the type, localization, severity, and timing of dyskinesias were evaluated in 15 parkinsonian patients in relation to motor disability after administration of levodopa using a video‐electromyographic recording device. Foot‐dystonia, myoclonus, and akathisia were observed in most patients. The dyskinesias started in the foot, usually on the side most affected by the disease, and spread in an “ascending wave” to the contralateral side, the trunk, and upper extremities. In a few patients, onset was axial, spreading almost instantaneously to all limbs. The dyskinesias were dystonic and ballistic at the start, and became increasingly choreic as they attained the upper limbs. Their intensity was maximal in the lower limbs, then progressively decreased, while increasing in upper limbs and head. The results indicate that there is no strict dichotomy between biphasic and monophasic dyskinesias. In other words, there is a “continuum” between the first dyskinesias and those observed during the period of maximal clinical improvement. These dyskinesias can also appear in reverse order, as if there were an “oscillator” determining a sequence of alternating patterns.

Url:

https://api.istex.fr/document/47A4FE5EDF56187C2710121CE25D3FC003824AE1/fulltext/pdf

DOI: 10.1002/mds.870090103

Affiliations:

France, Italie
Lille, Paris

Links to Exploration step

ISTEX:47A4FE5EDF56187C2710121CE25D3FC003824AE1

Le document en format XML

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</author>
<author><name sortKey="Lefebvre Aparros, Dominique" sort="Lefebvre Aparros, Dominique" uniqKey="Lefebvre Aparros D" first="Dominique" last="Lefebvre-Caparros">Dominique Lefebvre-Caparros</name>
</author>
<author><name sortKey="Bonnet, Anne Arie" sort="Bonnet, Anne Arie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name>
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<author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
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<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (classification)</term>
<term>Adult</term>
<term>Aged</term>
<term>Chorea (chemically induced)</term>
<term>Chorea (physiopathology)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Administration Schedule</term>
<term>Dyskinesia</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Dyskinesia, Drug-Induced (physiopathology)</term>
<term>Dyskinesias</term>
<term>Dystonia (chemically induced)</term>
<term>Dystonia (physiopathology)</term>
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<term>Human</term>
<term>Humans</term>
<term>Levodopa</term>
<term>Levodopa (administration & dosage)</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (drug effects)</term>
<term>Motor Activity (physiology)</term>
<term>Motor Skills (drug effects)</term>
<term>Neurologic Examination (drug effects)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (physiopathology)</term>
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<term>Pathophysiology</term>
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<term>Receptors, Dopamine D1 (physiology)</term>
<term>Toxicity</term>
<term>Video Recording</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electromyography</term>
<term>Motor Activity</term>
<term>Motor Skills</term>
<term>Neurologic Examination</term>
<term>Receptors, Dopamine D1</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term>
<term>Receptors, Dopamine D1</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Chorea</term>
<term>Dyskinesia, Drug-Induced</term>
<term>Dystonia</term>
<term>Parkinson Disease</term>
<term>Parkinson Disease, Secondary</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Administration Schedule</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Video Recording</term>
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<front><div type="abstract" xml:lang="en">The aim of this study was to provide further insight into the phenomenology and pathophysiology of monophasic and biphasic dyskinesias induced by levodopa in Parkinson's disease. For this purpose, the type, localization, severity, and timing of dyskinesias were evaluated in 15 parkinsonian patients in relation to motor disability after administration of levodopa using a video‐electromyographic recording device. Foot‐dystonia, myoclonus, and akathisia were observed in most patients. The dyskinesias started in the foot, usually on the side most affected by the disease, and spread in an “ascending wave” to the contralateral side, the trunk, and upper extremities. In a few patients, onset was axial, spreading almost instantaneously to all limbs. The dyskinesias were dystonic and ballistic at the start, and became increasingly choreic as they attained the upper limbs. Their intensity was maximal in the lower limbs, then progressively decreased, while increasing in upper limbs and head. The results indicate that there is no strict dichotomy between biphasic and monophasic dyskinesias. In other words, there is a “continuum” between the first dyskinesias and those observed during the period of maximal clinical improvement. These dyskinesias can also appear in reverse order, as if there were an “oscillator” determining a sequence of alternating patterns.</div>
</front>
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Movement Disorders (revue)

Levodopa‐induced dyskinesias in Parkinson's disease phenomenology and pathophysiology

Levodopa‐induced dyskinesias in Parkinson's disease phenomenology and pathophysiology

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.